Scorrano F, Carrasco J, Pastor-Ciurana J, Belda X, Rami A, Bacci ML, Armario A. Validation of the long-term assessment of hypothalamic-pituitary-adrenal activity in rats using hair corticosterone as a biomarker. FASEB Journal, 2014, accepted.

Daviu N, Andero R, Armario A, Nadal R. Sex differences in the behavioural and hypothalamic-pituitary-adrenal response to contextual fear conditioning in rats. Horm Behav. 2014, Epub ahead of print.

Fuentes S, Carrasco J, Armario A, Nadal R. Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats. Horm Behav. 2014;66(3):475-86.

Daviu N, Rabasa C, Nadal R, Armario A. Comparison of the effects of single and daily repeated immobilization stress on resting activity and heterotypic sensitization of the hypothalamic-pituitary-adrenal axis. Stress. 2014, 17(2):176-85.

Fuentes S, Daviu N, Garrido P, Gagliano H, Zelena D, Monasterio N, Armario A, Nadal R. Sex-dependent effects of an early life treatment in rats that increases maternal care: vulnerability or resilience? Front Behavioral Neurosci. 2014, 8:56.

Pastor-Ciurana J, Rabasa C, Ortega-Sánchez JA, Sanchís M, Gabriel-Salazar M, Ginesta M, Belda X, Daviu N, Nadal R, Armario A. Prior exposure to repeated immobilization or chronic unpredictable stress protects from some negative sequels of an acute immobilization Behav Brain Res. 2014, 265:155-62.

Echeverry-Alzate V, Giné E, Bühler K, Olmos P, Gorriti MA, Nadal R, Rodriguez de Fonseca F, López-Moreno JA. The Effects of Topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. British J Pharmacol. 2014, 171(12):3023-36.

Feliu-Soler A, Pascual JC, Borràs X, Portella MJ, Martín-Blanco A, Armario A, Alvarez E, Pérez V, Soler J. Effects of dialectical behaviour therapy-mindfulness training on emotional reactivity in borderline personality disorder: preliminary results. Clin Psychol Psychother. 2014;21(4):363-70.

Gagliano H, Delgado-Morales R, Sanz-Garcia A, Armario A. High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response. Neuropharmacology. 2014, 79:75-82.


Armario A, Nadal R. Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity. Frontiers in Pharmacol. 2013, 4, A137.

Rabasa C, Delgado-Morales R, Gómez-Román A, Nadal R, Armario A. Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water. Stress. 2013, 16(6):698-705.

Rotllant D, Pastor-Ciurana J, Armario A. Stress-induced brain histone H3 phosphorylation: contribution of the intensity of stressors and length of exposure. J Neurochem. 2013, 125(4):599-609.

Armario A, Nadal R. Searching for biological markers of personality: are there neuroendocrine markers of anxiety?. In: Durbano F (Ed.) New insights into anxiety disorders. InTech. 2013, 71-104.

Feliu-Soler A, Pascual JC, Soler J, Pérez V, Armario A, Carrasco J, Sanz A, Villamarín F, Borràs X. Emotional responses to a negative emotion induction procedure in Borderline Personality Disorder. Internat J Clinic Health Psychol. 2013, 13:9-17.


Daviu N, Delgado‐Morales R, Nadal R, Armario A. Not all stressors are equal: behavioural and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization. Front Behavioral Neurosci. 2012, 6:69.

Fodor A, Klausz B, Pintér O, Daviu N, Rabasa C, Rotllant D, Balazsfi D, Kovacs KB, Nadal R, Zelena D. Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin. Horm Behav. 2012, 62(4):539-51.

Belda X, Daviu N, Nadal R, Armario A. Acute-stress induced sensitization of the pituitary-adrenal response to heterotypic stressors: independence of glucocorticoid release and activation of CRH1 receptors. Horm Behav. 2012, 62(4):515-24.

Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012, 37(11):1745-54.

Armario A, Daviu N, Muñoz-Abellán C, Rabasa C, Fuentes S, Belda X, Gagliano H, Nadal R. What can we know from pituitary-adrenal hormones about the nature and consequences of exposure to emotional stressors? Cell Mol Neurobiol. 2012, 32(5):749-58.

Delgado-Morales R, del Río E, Gómez-Román A, Bisagno V, Nadal R, de Felipe C, Armario A. Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice. Physiol Behav. 2012, 105(3):669-75.

Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus. 2012, 22(3):399-408.

Rotllant D, Armario A. Brain pattern of histone H3 phosphorylation after acute amphetamine administration: Its relationship to brain c-fos induction is strongly dependent on the particular brain area. Neuropharmacology. 2012, 62(2):1073-81.

López-Gallardo M, López-Rodríguez AB, Llorente-Berzal Á, Rotllant D, Mackie K,Armario A, Nadal R, Viveros MP. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience. 2012, 204:90-103. 

Ribeiro Do Couto B, Daza-Losada M, Rodríguez-Arias M, Nadal R, Guerri C, Summavielle T, Miñarro J, Aguilar MA. Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding ffects of MDMA and drug-induced reinstatement. Addict Biol. 2012, 17(3):588-600.

Hoffmann HM, Nadal R, Vignes M, Ortiz J. Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addict Biol. 2012, 17(3):565-75. 


Muñoz-Abellán C, Rabasa C, Daviu N, Nadal R, Armario A. Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence? PLoS One. 2011, 6(6):e21426.

Llorente-Berzal  A, Fuentes S, Gagliano H, López-Gallardo M, Armario A, Viveros MP, Nadal R. Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour. Addict Biol. 2011, 16(4):624-37.

Alobid I, de Pablo J, Mullol J, Centellas S, Parramon G, Carrasco J, Armario A, Bernal-Sprekelsen M. Increased cardiovascular and anxiety outcomes but not endocrine biomarkers of stress during performance of endoscopic sinus surgery: a pilot study among novice surgeons. Arch Otolaryngol Head Neck Surg. 2011, 137(5):487-92.

Do Couto BR, Rodríguez-Arias M, Fuentes S, Gagliano H, Armario A, Miñarro J, Aguilar MA. Adolescent pre-exposure to ethanol or MDMA prolongs the conditioned rewarding effects of MDMA. Physiol Behav. 2011, 103(5):585-93.

Rabasa C, Muñoz-Abellán C, Daviu N, Nadal R, Armario A. Repeated exposure to immobilization or two different footshock intensities reveals differential adaptation of the hypothalamic-pituitary-adrenal axis. Physiol Behav. 2011, 103(2):125-33.

Rabasa C, Delgado-Morales R, Muñoz-Abellán C, Nadal R, Armario A. Adaptation of the hypothalamic-pituitary-adrenal axis and glucose to repeated immobilization or restraint stress is not influenced by associative signals. Behav Brain Res. 2011, 217(1):232-9.

Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ. Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning. Am J Psychiatry. 2011, 168(2):163-72. 


Ons S, Rotllant D, Marín-Blasco IJ, Armario A. Immediate-early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c-fos mRNA to adaptation. Eur J Neurosci. 2010, 31(11):2043-52.

Armario A. Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome. Trends Pharmacol Sci. 2010, 31(7):318-25.

Daviu N, Fuentes S, Nadal R, Armario A. A single footshock causes long-lasting hypoactivity in unknown environments that is dependent on the development of contextual fear conditioning. Neurobiol Learn Mem. 2010, 94(2):183-90.

Rotllant D, Márquez C, Nadal R, Armario A. The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits. Neuroscience. 2010, 168(3):691-705.

Muñoz-Abellán C, Armario A, Nadal R. Do odors from different cats induce equivalent unconditioned and conditioned responses in rats? Physiol Behav. 2010, 99(3):388-94.


Gagliano H, Andero R, Armario A, Nadal R. Repeated amphetamine administration in rats revealed consistency across days and a complete dissociation between locomotor and hypothalamic-pituitary-adrenal axis effects of the drug. Psychopharmacology. 2009, 207(3):447-59.

Muñoz-Abellán C, Daviu N, Rabasa C, Nadal R, Armario A. Cat odor causes long-lasting contextual fear conditioning and increased pituitary-adrenal activation, without modifying anxiety. Horm Behav. 2009, 56(4):465-71.

Amador-Arjona A, Delgado-Morales R, Belda X, Gagliano H, Gallego X, Keck ME, Armario A, Dierssen M. Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder. J Psychiatr Res. 2010, 44(3):157-67.

Belda X, Armario A. Dopamine D1 and D2 dopamine receptors regulate immobilization stress-induced activation of the hypothalamus-pituitary-adrenal axis. Psychopharmacology. 2009, 206(3):355-65.

Peña Y, Prunell M, Rotllant D, Armario A, Escorihuela RM. Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats. Psychoneuroendocrinology. 2009, 34(9):1390-404.


Belda X, Rotllant D, Fuentes S, Delgado R, Nadal R, Armario A. Exposure to severe stressors causes long-lasting dysregulation of resting and stress-induced activation of the hypothalamic-pituitary-adrenal axis. Ann N Y Acad Sci. 2008, 1148:165-73.

Belda X, Fuentes S, Nadal R, Armario A. A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors. Horm Behav. 2008, 54(5):654-61.

Muñoz-Abellán C, Andero R, Nadal R, Armario A. Marked dissociation between hypothalamic-pituitary-adrenal activation and long-term behavioral effects in rats exposed to immobilization or cat odor. Psychoneuroendocrinology. 2008, 33(8):1139-50.

Armario A, Escorihuela RM, Nadal R. Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals. Neurosci Biobehav Rev. 2008, 32(6):1121-35.

Carrasco J, Márquez C, Nadal R, Tobeña A, Fernández-Teruel A, Armario A. Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains. Psychoneuroendocrinology. 2008, 33(4):437-45.

Gagliano H, Fuentes S, Nadal R, Armario A. Previous exposure to immobilisation and repeated exposure to a novel environment demonstrate a marked dissociation between behavioral and pituitary-adrenal responses. Behav Brain Res. 2008, 187(2):239-45.


Dimitsantos E, Escorihuela RM, Fuentes S, Armario A, Nadal R. Litter size affects emotionality in adult male rats. Physiol Behav. 2007, 92(4):708-16.

Rotllant D, Nadal R, Armario A. Differential effects of stress and amphetamine administration on Fos-like protein expression in corticotrophin releasing factor-neurons of the rat brain. Dev Neurobiol. 2007, 67(6):702-14.

Trnecková L, Rotllant D, Klenerová V, Hynie S, Armario A. Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: evidence against a critical role of the termination of exposure to the stressor. J Neurochem. 2007, 100(4):905-14.


Armario A. The hypothalamic-pituitary-adrenal axis: what can it tell us about stressors? CNS Neurol Disord Drug Targets. 2006;5(5):485-501.

Armario A. The contribution of immediate early genes to the understanding of brain processing of stressors. IN: Immediate early genes in sensory processing, cognitive performance and neurological disorders; R Pinaud and L Tremere Eds, Springer Science+Business Media, 2006, pp. 199-221.

Peña Y, Prunell M, Dimitsantos V, Nadal R, Escorihuela RM. Environmental enrichment effects in social investigation in rats are gender dependent. Behav Brain Res. 2006;174(1):181-7.

Vallès A, Martí O, Armario A. Long-term effects of a single exposure to immobilization: a c-fos mRNA study of the response to the homotypic stressor in the rat brain. J Neurobiol. 2006;66(6):591-602.

Ribeiro Do Couto B, Aguilar MA, Manzanedo C, Rodríguez-Arias M, Armario A, Miñarro J. Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice. Psychopharmacology. 2006;185(4):459-70.

Trnecková L, Armario A, Hynie S, Sída P, Klenerová V. Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague-Dawley rats. Brain Res. 2006;1077(1):7-15.

Márquez C, Nadal R, Armario A. Influence of reactivity to novelty and anxiety on hypothalamic-pituitary-adrenal and prolactin responses to two different novel environments in adult male rats. Behav Brain Res. 2006;168(1):13-22.

Nadal R, Escorihuela RM, Armario A .The elevated plus-maze test of anxiety: methodological considerations. In: Anderson MJ (Ed.) Tasks and techniques: a sampling of the methodologies for the investigation of animal learning, behavior and cognition. Nova Science Publishers, NY, 2006, 25-37.


Nadal R, Rotllant D, Márquez C, Armario A. Perseverance of exploration in novel environments predicts morphine place conditioning in rats. Behav Brain Res. 2005, 165(1):72-9.

Vallès A, Martí O, Armario A. Mapping the areas sensitive to long-term endotoxin tolerance in the rat brain: a c-fos mRNA study. J Neurochem. 2005, 93(5):1177-88.

Belda X, Ons S, Carrasco J, Armario A. The effects of chronic food restriction on hypothalamic-pituitary-adrenal activity depend on morning versus evening availability of food. Pharmacol Biochem Behav. 2005, 81(1):41-6.

Rotllant D, Armario A. A single dose of metyrapone caused long-term dysregulation of the hypothalamic-pituitary-adrenal axis in the rat. Neuroscience. 2005, 130(2):427-34.

Márquez C, Nadal R, Armario A. Responsiveness of the hypothalamic-pituitary-adrenal axis to different novel environments is a consistent individual trait in adult male outbred rats. Psychoneuroendocrinology. 2005, 30(2):179-87.


Armario A, Vallès A, Dal-Zotto S, Márquez C, Belda X. A single exposure to severe stressors causes long-term desensitisation of the physiological response to the homotypic stressor. Stress. 2004, 7(3):157-72.

Belda X, Márquez C, Armario A. Long-term effects of a single exposure to stress in adult rats on behavior and hypothalamic-pituitary-adrenal responsiveness: comparison of two outbred rat strains. Behav Brain Res. 2004, 154(2):399-408.

Armario A, Martí O, Vallès A, Dal-Zotto S, Ons S. Long-term effects of a single exposure to immobilization on the hypothalamic-pituitary-adrenal axis: neurobiologic mechanisms. Ann N Y Acad Sci. 2004, 1018:162-72.

Dal-Zotto S, Martí O, Delgado R, Armario A. Potentiation of glucocorticoid release does not modify the long-term effects of a single exposure to immobilization stress. Psychopharmacology (Berl). 2004, 177(1-2):230-7.

Ons S, Martí O, Armario A. Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. J Neurochem. 2004, 89(5):1111-8.

Márquez C, Nadal R, Armario A. The hypothalamic-pituitary-adrenal and glucose responses to daily repeated immobilisation stress in rats: individual differences. Neuroscience. 2004, 123(3):601-12.


Bertuzzi ML, Bensi N, Mayer N, Niebylski A, Armario A, Gauna HF. Renal mechanisms involved in stress-induced antinatriuresis and antidiuresis in rats. Arch Physiol Biochem. 2003, 111(3):259-64.

Dal-Zotto S, Martí O, Armario A. Glucocorticoids are involved in the long-term effects of a single immobilization stress on the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology. 2003, 28(8):992-1009.

Vallès A, Martí O, Armario A. Long-term effects of a single exposure to immobilization stress on the hypothalamic-pituitary-adrenal axis: transcriptional evidence for a progressive desensitization process. Eur J Neurosci. 2003, 18(6):1353-61.

Finn DP, Martí O, Harbuz MS, Vallès A, Belda X, Márquez C, Jessop DS, Lalies MD, Armario A, Nutt DJ, Hudson AL. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology. 2003, 167(2):195-202.


Rotllant D, Ons S, Carrasco J, Armario A. Evidence that metyrapone can act as a stressor: effect on pituitary-adrenal hormones, plasma glucose and brain c-fos induction. Eur J Neurosci. 2002, 16(4):693-700.

Nadal R, Armario A, Janak PH. Positive relationship between activity in a novel environment and operant ethanol self-administration in rats. Psychopharmacology. 2002, 162(3):333-8.

Vallès A, Martí O, Harbuz MS, Armario A. A single lipopolysaccharide administration is sufficient to induce a long-term desensitization of the hypothalamic-pituitary-adrenal axis. Neuroscience. 2002, 112(2):383-9.

Márquez C, Belda X, Armario A. Post-stress recovery of pituitary-adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situations. Brain Res. 2002, 926(1-2):181-5.

Dal-Zotto S, Martí O, Armario A. Is repeated exposure to immobilization needed to induce adaptation of the hypothalamic-pituitary-adrenal axis? Influence of adrenal factors. Behav Brain Res. 2002, 129(1-2):187-95.


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